9C1W Chain A
RAC-beta serine/threonine-protein kinase (AKT2)
Inactive — 0.0%DFG-outαC-outAllosteric · XOO
Resolution
2.0 Å
R-value
0.207
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAAAEDKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD
UniProt reference sequence
FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
Aligned reference sequence
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVII------------------------------AHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Activation segment
DFGL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKILHTVTESRVLQNTRPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGLC
Ligand info
Orthosteric ligand
XOO
Allosteric ligand
None
Ligand typeAllosteric
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 9C1W, Chain A