9C1R Chain A
Hepatocyte growth factor receptor (MET)
Inactive — 31.6%DFG-outαC-inType2 · A1ATS
Resolution
1.59 Å
R-value
0.17
Predicted activity confidence31.6%
Structure info
Alternate conformationA
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHHHHH
UniProt reference sequence
LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
Aligned reference sequence
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKEYY--SVHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGAKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWMALE
Binding pocket
EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFG__
Ligand info
Orthosteric ligand
A1ATS
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 9C1R, Chain A