8XYB Chain C
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
Active — 100.0%DFG-inαC-in
Resolution
3.1 Å
R-value
999.0
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSL
UniProt reference sequence
YEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF
Aligned reference sequence
YEPK----------------EILGRGV----------------SSVVRRCIH--KP------------------------------------TSQEYAVKVID--VTGGGSFSPEEVREL-------------------REATLKEVDILRKV--S-----------------------GHPNIIQLKDTYETNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFFLVFDLMKR--------------GELFDYLTE--KV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEKETRKIMRALLEVICTLHKL---------------------------------------------NIVHRDL-----KPENILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKLTDFGFSCQLEPGERL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REVCGTPSYLAPEIIEC--SMNEDH------------------------PGYG-KEVDMWSTGVIMYTLLAG-----------------SPPFWH--------------------------------------------------RKQMLMLRMIMSG--NYQFGSPEWDDYS--------------------------------------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT--------------AEEALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEPK----------------EILGRGV----------------SSVVRRCIH--KP------------------------------------TSQEYAVKVID--VTGGGSFSPEEVREL-------------------REATLKEVDILRKV--S-----------------------GHPNIIQLKDTYETNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFFLVFDLMKR--------------GELFDYLTE--KV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEKETRKIMRALLEVICTLHKL---------------------------------------------NIVHRDL-----KPENILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKLTDFGFSCQLEPGERL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REVCGTPSYLAPEIIEC--SMNEDH------------------------PGYG-KEVDMWSTGVIMYTLLAG-----------------SPPFWH--------------------------------------------------RKQMLMLRMIMSG--NYQFGSPEWDDYS--------------------------------------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT--------------AEEALAHPFF
Activation segment
DFGFSCQLEPGERL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REVCGTPSYLAPE
Binding pocket
EILGRGVSSVVRRYAVKVIATLKEVDILRKVSPNIIQLKDTFLVFDLMKRGELFDYLTETLHKLNIVHRDLKPENILLLTDFGFS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8XYB, Chain C