8XPZ Chain A
Tau-tubulin kinase 1 (TTBK1)
Active — 98.5%DFG-inαC-in
Resolution
2.6 Å
R-value
0.205
Predicted activity confidence98.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEK
UniProt reference sequence
WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFEN
Aligned reference sequence
WKVL----------------KKIGGGG----------------FGEIYEAMD--LL------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QPRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLSTTLRLGKQILESIEAIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--LPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRKCYMLDFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVNAHKN--------------------------------REMG-RHDDLWSLFYMLVEFAVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGMIKEKY--EHRMLLKHMP-----------------------------------------------------------------------------------------------------SEFHLFLDHIASLDYFTKPD--------------YQLIMSVFEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WKVL----------------KKIGGGG----------------FGEIYEAMD--LL------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QPRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLSTTLRLGKQILESIEAIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--LPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRKCYMLDFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVNAHKN--------------------------------REMG-RHDDLWSLFYMLVEFAVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGMIKEKY--EHRMLLKHMP-----------------------------------------------------------------------------------------------------SEFHLFLDHIASLDYFTKPD--------------YQLIMSVFEN
Activation segment
DFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVN
Binding pocket
KKIGGGGFGEIYEVALKVEVLKMEVAVLKKLQDHVCRFIGCYVVMQLQG_RNLADLRRSAIHSVGFLHRDIKPSNFAMMLDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8XPZ, Chain A