8XOV Chain A
Ribosomal protein S6 kinase alpha-1 (RPS6KA2)
Inactive — 0.0%DFG-inαC-outATPlike · ANP
Resolution
2.55 Å
R-value
0.206
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP
UniProt reference sequence
FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
Aligned reference sequence
FELL----------------KVLGQGS----------------YGKVFLVRK--VKGSD---------------------------------AGQLYAMKVLK--KATLKVRD--------------------------RVRSKMERDILAEV--------------------------NHPFIVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDLFTRLSK--EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL---------------------------------------------GIIYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKITDFGLSKEAIDHDKR--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSFCGTIEYMAPEVVNR--------------------------------RGHT-QSADWWSFGVLMFEMLTG-----------------SLPFQG--------------------------------------------------KDRKETMALILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLG--AGIDG-------VEEIKRHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELL----------------KVLGQGS----------------FGKVFLVRK--VTRPD---------------------------------SGHLYAMKVLK----------------------------------------KMERDILADV--------------------------NHPFVVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDLFTRLSK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTEEDVKFYLAELALGLDHLHSL---------------------------------------------GIIYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSKEA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTVEYMAPEVVNR--------------------------------QGHS-HSADWWSYGVLMFEMLTG-----------------SLPFQG--------------------------------------------------KDRKETMTLILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------TEAQSLLRALFKRNPANRLG--SGPDG-------AEEIKRHVFP
Activation segment
DFGLSKEA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTVEYMAPE
Binding pocket
KVLGQGSFGKVFLYAMKVL___MERDILADVNPFVVKLHYAYLILDFLRGGDLFTRLSKHLHSLGIIYRDLKPENILLLTDFGLS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8XOV, Chain A