8XFL Chain A
MAP/microtubule affinity-regulating kinase 4 (MARK4)
Inactive — 0.0%DFG-inαC-out
Resolution
3.0 Å
R-value
0.21
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTPPYAAPELGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRK
UniProt reference sequence
YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
Aligned reference sequence
YRLL----------------RTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPSS--------------------------LQKLFREVRIMKGL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLVMEYASA--------------GEVFDYLVS--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EANIKIADFGFSNEFTLGSKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFCGSPPYAAPELFQG--------------------------------KKYDGPEVDIWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------HNLKELRERVLRG--KYRVPFYMS------------------------------------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT--------------LEQIMKDKWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLL----------------RTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPSS--------------------------LQKLFREVRIMKGL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLVMEYASA--------------GEVFDYLVS--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EANIKIADFGFSNEFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPYAAPEL---------------------------------------GPEVDIWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------HNLKELRERVLRG--KYRVPFYMS------------------------------------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT--------------LEQIMKDKWI
Activation segment
DFGFSNEFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPYAAPE
Binding pocket
RTIGKGNFAKVKLVAIKIIKLFREVRIMKGLNPNIVKLFEVYLVMEYASAGEVFDYLVSYCHQKNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8XFL, Chain A