8X2A Chain A
Cytoplasmic tyrosine-protein kinase BMX (BMX)
Inactive — 0.0%DFG-inαC-outType1 · LTJ
Resolution
1.3 Å
R-value
0.129
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLRE
UniProt reference sequence
ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEP
Aligned reference sequence
ITLL----------------KELGSGQ----------------FGVVQLGKW--K-------------------------------------GQYDVAVKMIK--EGSMS-----------------------------EDEFFQEAQTMMKL--------------------------SHPKLVKFYGVCSKEY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYISN--------------GCLLNYLRS--HGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLEPSQLLEMCYDVCEGMAFLESH---------------------------------------------QFIHRDL-----AARNCLVDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCVKVSDFGMTRYVLDDQYV--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPEVFHY--------------------------------FKYS-SKSDVWAFGILMWEVFSL--G--------------KQPYDL--------------------------------------------------YDNSQVVLKVSQG--HRLYRPHLAS-----------------------------------------------------------------------------------------------------DTIYQIMYSCWHELPEKRPT--------------FQQLLSSIEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------KELGSGQ----------------FGVVQLGKW--K-------------------------------------GQYDVAVKMIK--EGSMS-----------------------------EDEFFQEAQTMMKL--------------------------SHPKLVKFYGVCSKEY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYISN--------------GCLLNYLRS--HGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLEPSQLLEMCYDVCEGMAFLESH---------------------------------------------QFIHRDL-----AARNCLVDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCVKVSDFGMTRYVLDDQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPEVFHY--------------------------------FKYS-SKSDVWAFGILMWEVFSL--G--------------KQPYDL--------------------------------------------------YDNSQVVLKVSQG--HRLYRPHLAS-----------------------------------------------------------------------------------------------------DTIYQIMYSCWHELPEKRPT--------------FQQLLSSIEP
Activation segment
DFGMTRYVLDDQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPE
Binding pocket
KELGSGQFGVVQLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTEYISNGCLLNYLRSFLESHQFIHRDLAARNCLVVSDFGMT
Ligand info
Orthosteric ligand
LTJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8X2A, Chain A