8X23 Chain A
Mitogen-activated protein kinase 13 (MAPK13)
Inactive — 0.0%DFG-inαC-in
Resolution
1.5 Å
R-value
0.126
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP
UniProt reference sequence
YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
Aligned reference sequence
YVSP----------------THVGSGA----------------YGSVCSAID--KR------------------------------------SGEKVAIKKLS--RPFQSEIF--------------------------AKRAYRELLLLKHM--------------------------QHENVIGLLDVFTPAS--SLRNFY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMQ---------------TDLQKIMGM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSEEKIQYLVYQMLKGLKYIHSA---------------------------------------------GVVHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARHADAEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILS--W-----------------------------MHYN-QTVDIWSVGCIMAEMLTG-----------------KTLFKG--------------------------------------------------KDYLDQLTQILKV--TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS-----------------------------------------------------------------------PQAADLLEKMLELDVDKRLT--------------AAQALTHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVSP----------------THVGSGA----------------YGSVCSAID--KR------------------------------------SGEKVAIKKLS--RPFQSEIF--------------------------AKRAYRELLLLKHM--------------------------QHENVIGLLDVFTPAS--SLRNFY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMQ---------------TDLQKIMGM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSEEKIQYLVYQMLKGLKYIHSA---------------------------------------------GVVHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILS--W-----------------------------MHYN-QTVDIWSVGCIMAEMLTG-----------------KTLFKG--------------------------------------------------KDYLDQLTQILKV--TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS-----------------------------------------------------------------------PQAADLLEKMLELDVDKRLT--------------AAQALTHPFF
Activation segment
DFGLAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPE
Binding pocket
THVGSGAYGSVCSVAIKKLRAYRELLLLKHMQENVIGLLDVYLVMPFMQ_TDLQKIMGMYIHSAGVVHRDLKPGNLAVILDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8X23, Chain A