8WM0 Chain A
TRAF2 and NCK-interacting protein kinase (TNIK)
Active — 81.4%DFG-inαC-inType1 · ADN
Resolution
2.8 Å
R-value
0.233
Predicted activity confidence81.4%
Structure info
Alternate conformationA
Missing atoms8
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRVGRRNFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTK
UniProt reference sequence
FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
Aligned reference sequence
FELV----------------ELVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTGDE-----------------------------EEEIKQEINMLKKY--S-----------------------HHRNIATYYGAFIKKN--PPGMDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSVTDLIKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQH---------------------------------------------KVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-FKSDLWSLGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PAPRLKSKKWS----------------------------------------------------------------------------------------------------KKFQSFIESCLVKNHSQRPA--------------TEQLMKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------ELVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTGDE-----------------------------EEEIKQEINMLKKY--S-----------------------HHRNIATYYGAFIKKN--PPGMDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSVTDLIKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQH---------------------------------------------KVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDR-VGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FIGTPYWMAPEVIAC--DENPD-------------------------ATYD-FKSDLWSLGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PAPRLKSKKWS----------------------------------------------------------------------------------------------------KKFQSFIESCLVKNHSQRPA--------------TEQLMKHPFI
Activation segment
DFGVSAQLDR-VGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FIGTPYWMAPE
Binding pocket
ELVGNGTYGQVYKAAIKVMEIKQEINMLKKYSRNIATYYGAWLVMEFCGAGSVTDLIKNHLHQHKVIHRDIKGQNVLLLVDFGVS
Ligand info
Orthosteric ligand
ADN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8WM0, Chain A