8VSU Chain C
Serine/threonine-protein kinase STK11 (STRADA)
Inactive — 39.3%DFG-outαC-out
Resolution
2.86 Å
R-value
999.0
Predicted activity confidence39.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGA
UniProt reference sequence
YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFF
Aligned reference sequence
YELL----------------TVIGKGF--ED------------LMTVNLARY--KP------------------------------------TGEYVTVRRIN--LEACSNEM--------------------------VTFLQGELHVSKLF--------------------------NHPNIVPYRATFIADN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVTSFMAY--------------GSAKDLICT--HFMD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMNELAIAYILQGVLKALDYIHHM---------------------------------------------GYVHRSV-----KASHILISV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGKVYLSGLRSNLSMISHGQR--QRVVHDFP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSVKVLPWLSPEVLQQ--NL----------------------------QGYD-AKSDIYSVGITACELANG-----------------HVPFKD--------------------------------------------------MPATQMLLEKLNG--TVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFS--------------------------------------------------------PHFHHFVEQCLQRNPDARPS--------------ASTLLNHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
GDLL----------------GSYGKVK--EV------------LDSETLCRV--KI------------------------------------LKKKKLRRIPN--GEANVKKE--------------------------IQLLRRLRHVDVLY--------------------------NEEKQKMY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVMEYCVC--------------GMQEMLDSV--PEKR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPVCQAHGYFCQ-LIDGLEYLHSQ---------------------------------------------GIVHKDI-----KPGNLLLTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLKISDL-----GVAEALH--PFAADDTC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPEIANG--LD----------------------------TFSG-FKVDIWSAGVTLYNITTG-----------------LYPF------------------------------------------------------------EGDNI--YKLFENIGKGSYAIPGDCGP-------PLSDLLYEPAKRFSIRQIRQHSWFRKKH--------------------------------------------------------PPAEAPVPIPPSPDTKDRWR--------------SMTLEDLHGA
Activation segment
DL-----GVAEALH--PFAADDTC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPE
Binding pocket
SYGLAVKILVKKEIQLLRRLRKNVIQLVDVMGM__DSYLHSQGIVHKDIKPGNLLLISDVA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8VSU, Chain C