8VSU Chain B
STE20-related kinase adapter protein alpha (STK11)
Active — 97.5%DFG-outαC-outATPlike · ADP
Resolution
2.86 Å
R-value
999.0
Predicted activity confidence97.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues8
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPIT
UniProt reference sequence
YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
Aligned reference sequence
YLMG----------------DLLGEGS----------------YGKVKEVLD--SE------------------------------------TLCRRAVKILK--KKKLRRIPNG------------------------EANVKKEIQLLRRL--------------------------RHKNVIQLVDVLYNEE--KQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMYMVMEYCV---------------CGMQEMLDS--VPEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFPVCQAHGYFCQLIDGLEYLHSQ---------------------------------------------GIVHKDI-----KPGNLLLTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLKISDLGVAEALHPFAAD--DTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPEIANG--L-----------------------------DTFSGFKVDIWSAGVTLYNITTG-----------------LYPFEG--------------------------------------------------DNIYKLFENIGKG--SYAIPGDCG------------------------------------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS--------------IRQIRQHSWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
---S----------------SFLPEGV----------------IGKGFEDLM--TV------------------------------------NLAR--YKPTG--EYVTVRRINL------------------------EACSNEMVTFLQGE--------------------------LH------VSKLFNHP--NI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPYVVTSFMA---------------YGSAKDLIC--THFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMNELAIAYILQGVLKLDYIHHM---------------------------------------------GYVHRSV-----KASHILISV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGKVYLSGLMISHGQRQRVVH--DFP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSVKVLPWLSPEVLQQ--N-----------------------------LQGYDAKSDIYSVGITACELANG-----------------HVPFEK--------------------------------------------------LNGTVPCLLDTST--IHPYHRTFS------------------------------------------------------------------------------------------------------PHFHHFVEQCLQRNPDARPS--------------ASTLLNHSFF
Activation segment
GLMISHGQRQRVVH--DFP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSVKVLPWLSPE
Binding pocket
_LLT__VIGKGFER_YKPTCSNEMVTFLQGELKLFNHPNIVTSFMAY___GSAKDLICTYIHHMGYVHRSVKASHILIYS_VKVL
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8VSU, Chain B