8UDU Chain A
Fibroblast growth factor receptor 3 (FGFR3)
Inactive — 0.8%DFG-inαC-inType1.5_Back · WIQ
Resolution
1.737 Å
R-value
0.231
Predicted activity confidence0.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLANLDYYKGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSHHH
UniProt reference sequence
LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR
Aligned reference sequence
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RRPPGLDYSFDTCKPPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDVHNLDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RR------------SGEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLA----NLDYY--K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLA----NLDYY--K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPE
Binding pocket
KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVLVEYAAKGNLREFLRAYLASQKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
WIQ
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8UDU, Chain A