8UDT Chain A
Fibroblast growth factor receptor 3 (FGFR3)
Inactive — 0.2%DFG-inαC-inAllosteric,Allosteric,Type1.5_Front · WGF
Resolution
2.829 Å
R-value
0.263
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS
UniProt reference sequence
LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR
Aligned reference sequence
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RRPPGLDYSFDTCKPPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDVHNLDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RR------------SGEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDVHNLDYY--KKT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLARDVHNLDYY--KKT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWMAPE
Binding pocket
KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVLVEYAAKGNLREFLRAYLASQKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
WGF
Allosteric ligand
None
Ligand typeAllosteric,Allosteric,Type1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8UDT, Chain A