8U1L Chain C
RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Inactive — 0.0%DFG-outαC-out
Resolution
3.7 Å
R-value
999.0
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues41
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK
UniProt reference sequence
VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIEL
Aligned reference sequence
VMLS----------------TRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKILK--VVDPTPEQ--------------------------FQAFRNEVAVLRKT--------------------------RHVNILLFMGYMTKD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLAIVTQWCEG--------------SSLYKHLHV--QET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFQMFQLIDIARQTAQGMDYLHAK---------------------------------------------NIIHRDM-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTVKIGDFGLATVKSRWSGS--QQV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPTGSVLWMAPEVIRM--QDN---------------------------NPFS-FQSDVYSYGIVLYELMTG-----------------ELPYSH--I-----------------------------------------------NNRDQIIFMVGRG--YASPDLSKLYKNCP-------------------------------------------------------------------------------------------------KAMKRLVADCVKKVKEERPL--------------FPQILSSIEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIVTQWCEG--------------SSLYKHLHV--QET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFQMFQLIDIARQTAQGMDYLHAK---------------------------------------------NIIHRDM-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTVKIGDFGLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTGSVLWMAPEVIRM--QDN---------------------------NPFS-FQSDVYSYGIVLYELMTG-----------------ELPYSH--I-----------------------------------------------NNRDQIIFMVGRG--YASPDLSKLYKNCP-------------------------------------------------------------------------------------------------KAMKRLVADCVKKVKEERPL--------------FPQILSSIEL
Activation segment
DFGLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTGSVLWMAPE
Binding pocket
_________________________________________AIVTQWCEGSSLYKHLHVYLHAKNIIHRDMKSNNIFLIGDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8U1L, Chain C