8U1B Chain A
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
Inactive — 31.6%DFG-outαC-out
Resolution
3.7 Å
R-value
999.0
Predicted activity confidence31.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues16
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKINQQADVYSFGLLLYDILTTGGRELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATSIWLGCTDRGQLSFLDLTEGYTVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLKNVMLVLGYSCLTVWDINLPHEVQNLEKHIEVRKELAEKM
UniProt reference sequence
LEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS
Aligned reference sequence
LEFE--QAPE----------FLLGDGS----------------FGSVYRAAY----------------------------------------EGEEVAVKIFN--KHTS------------------------------LRLLRQELVVLCHL--------------------------HHPSLISLLAAGIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRMLVMELASK--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKIADYGIAQYCCRMGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSEGTPGFRAPEVARG--N-----------------------------VIYN-QQADVYSFGLLLYDILTT-----------------GGRIVE--GLKF--------------------------------------------PNEFDELEIQGKL--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-QQADVYSFGLLLYDILTT-----------------GGR----------------------------------------------------------ELEIQGKL--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Activation segment
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
ALADGRSAAIKI__________NQ_D_Y___YDILELI_GKLVKEILNSAELVRRILLPKNVMVLTDRGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8U1B, Chain A