8TZE Chain A
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
Inactive — 0.0%DFG-outαC-outType2 · T3X
Resolution
2.9 Å
R-value
999.0
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GIISRRDVEYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLLRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIPGFRAPEVARGYNQQADVYSFGLLLYDILTTGGRIVLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLESWIVSGTQSGTLLVINTEDGKHTLEKMTDSVTCLYCNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNREIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR
UniProt reference sequence
LEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS
Aligned reference sequence
LEFE--QAPE----------FLLGDGS----------------FGSVYRAAY----------------------------------------EGEEVAVKIFN--KHTS------------------------------LRLLRQELVVLCHL--------------------------HHPSLISLLAAGIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRMLVMELASK--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKIADYGIAQYCCRMGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSEGTPGFRAPEVARG--N-----------------------------VIYN-QQADVYSFGLLLYDILTT-----------------GGRIVE--GLKF--------------------------------------------PNEFDELEIQGKL--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEFE--QAPE----------FLLGDGS----------------FGSVYRAAY----------------------------------------EGEEVAVKIFN--KHTS------------------------------LRLLRQELVVLCHL--------------------------HHPSLISLLAAGIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRMLVMELASK--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKIADYGI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGFRAPEVARG----------------------------------YN-QQADVYSFGLLLYDILTT-----------------GGRIV---------------------------------------------------------------L--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Activation segment
DYGI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGFRAPE
Binding pocket
FLLGDGSFGSVYRVAVKIFLLRQELVVLCHLHPSLISLLAAMLVMELASKGSLDRLLQQYLHSAMIIYRDLKPHNVLL_______
Ligand info
Orthosteric ligand
T3X
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8TZE, Chain A