8TZC Chain A
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
Inactive — 13.9%DFG-inαC-out
Resolution
2.7 Å
R-value
999.0
Predicted activity confidence13.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NRMKLMIVGNTGSGKTLLQQLMATVGIDVKDWPVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDPWLFPVILVGTIRDYHFVRKTIINESLAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILKGIISRRDVEKFYFKLLEKFQIALPILLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSALRPNRMYWRQGIYLNWSPEAYCLVGSEVLPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYSIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVFDELEIGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVASIWLGCGQLSFLDLEGYTSEEVARILCLALIVSGTQSGTLLVINSVTCLYCLLVGTADGKLAIFPLKILNITPLMCLSESMWGGCGTKIFSFTIQKLIETRTSQLFSYAAFSDNIITVVVDTALYIAKQNSPVVEVWDKTEKLCGLIDCVHFLYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLKNVMLVLGYNRIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR
UniProt reference sequence
LEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS
Aligned reference sequence
LEFE--QAPE----------FLLGDGS----------------FGSVYRAAY----------------------------------------EGEEVAVKIFN--KHTS------------------------------LRLLRQELVVLCHL--------------------------HHPSLISLLAAGIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRMLVMELASK--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKIADYGIAQYCCRMGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSEGTPGFRAPEVARG--N-----------------------------VIYN-QQADVYSFGLLLYDILTT-----------------GGRIVE--GLKF--------------------------------------------PNEFDELEIQGKL--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEFE--QAPE----------FLLGDGS----------------FGSVYRAAY----------------------------------------EGEEVAVKIFN--KHTS------------------------------LRLLRQELVVLCHL--------------------------HHPSLISLLAAGIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRMLVMELASK--------------GSLDRLLQQ--DKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---------------------------------------------MIIYRDL-----KPHNVLLFT--LYPNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIAKIADYSIAQYCCRMGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSEGTPGFRAPEVARG--N-----------------------------VIYN-QQADVYSFGLLLYDILTT-----------------GGRIV------------------------------------------------------FDELEI-GKL--PDPVKEYGCAPW---------------------------------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT--------------SAQVFDILNS
Activation segment
DYSIAQYCCRMGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSEGTPGFRAPE
Binding pocket
SLFG_AFKLLYFWSRLEVLSFLDPGLLEY__SILALAPEYLHSAMIPIADFGLL
Ligand info
Orthosteric ligand
None
Allosteric ligand
A1N
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8TZC, Chain A