8SV9 Chain A
Serine/threonine-protein kinase ULK1 (ULK1)
Active — 88.6%DFG-inαC-inType1 · WXH
Resolution
2.3 Å
R-value
0.212
Predicted activity confidence88.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAALCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDAS
UniProt reference sequence
FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
Aligned reference sequence
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--REK-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLSN--PAGRRANPN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLCGSPMYMAPEVIMS--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------SSPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--RAA-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLSN--PAGRRANPN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LCGSPMYMAPEVIMS--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------SSPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Activation segment
DFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LCGSPMYMAPE
Binding pocket
DLIGHGAFAVVFKVAVKCILLGKEIKILKELKENIVALYDFYLVMEYCNGGDLADYLHALLHSKGIIHRDLKPQNILLIADFGFA
Ligand info
Orthosteric ligand
WXH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8SV9, Chain A