8S93 Chain A
Tyrosine-protein kinase BTK (BTK)
Inactive — 0.0%DFG-inαC-outType1 · 9AJ
Resolution
2.1 Å
R-value
0.201
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
MAAVILESIFLKRSQQKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVIPEKNPPPERQIPRRGAERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRGGGSGGGEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIRMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVMDEES
UniProt reference sequence
LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
Aligned reference sequence
LTFL----------------KELGTGQ----------------FGVVKYGKW--R-------------------------------------GQYDVAIKMIK--EGSMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIFIITEYMAN--------------GCLLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFGLSRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSKFPVRWSPPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLYRPHLAS-----------------------------------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT--------------FKILLSNILD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTFL----------------KELGTGQ----------------FGVVKYGKW--R-------------------------------------GQYDVAIRMIR--EGSMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIFIITEYMAN--------------GCLLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFGMTRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSKFPVKWASPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLPRPHLAS-----------------------------------------------------------------------------------------------------ERVYTIMYSCWHEKADERPS--------------FKILLSNILD
Activation segment
DFGMTRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSKFPVKWASPE
Binding pocket
KELGTGQFGVVKYVAIRMIEFIEEAKVMMNLSEKLVQLYGVFIITEYMANGCLLNYLREYLESKQFLHRDLAARNCLVVSDFGMT
Ligand info
Orthosteric ligand
9AJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8S93, Chain A