8RU8 Chain A
Cyclin-dependent kinase 2 (CDK2)
Inactive — 0.0%DFG-inαC-outType1 · I74
Resolution
1.51 Å
R-value
0.205
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MENFQKVEKLGEGQYGVVYKARNKLTGEVVALKKIRSTAIREISLLKELNHPNIIKLLDVIHTENKLYLVFEFLHQDLEVFMKASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPNNLLINTEGAIKLADFHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
UniProt reference sequence
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Aligned reference sequence
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--LDTETEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPVRT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQKV----------------EKLGEGQ----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR-------------------------------------STAIREISLLKEL--------------------------NHPNIIKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLEVFMKA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPNNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Activation segment
DF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEVVTLWYRAPE
Binding pocket
EKLGEGQYGVVYKVALKKITAIREISLLKELNPNIIKLLDVYLVFEFLH_QDLEVFMKAFCHSHRVLHRDLKPNNLLILADF___
Ligand info
Orthosteric ligand
I74
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8RU8, Chain A