8R4V Chain A
Serine/threonine-protein kinase SIK3 (SIK3)
Active — 100.0%DFG-inαC-inType1 · XWA
Resolution
1.9 Å
R-value
0.206
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms14
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAESQQLKPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDR
UniProt reference sequence
YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM
Aligned reference sequence
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------CHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTWCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------SHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHSR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Activation segment
DFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPE
Binding pocket
RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLSPHIIRLYQVYLVTEYASGGEIFDHLVAFCHSRNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
XWA
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8R4V, Chain A