8R4U Chain A
Serine/threonine-protein kinase SIK3 (SIK3)
Active — 99.5%DFG-inαC-inType1.5_Front · XW3
Resolution
2.416 Å
R-value
0.23
Predicted activity confidence99.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAESQQLKPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCD
UniProt reference sequence
YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM
Aligned reference sequence
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------CHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTWCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------SHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHSR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Activation segment
DFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPE
Binding pocket
RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLSPHIIRLYQVYLVTEYASGGEIFDHLVAFCHSRNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
XW3
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8R4U, Chain A