8R4O Chain A
Serine/threonine-protein kinase SIK3 (SIK3)
Active — 93.4%DFG-inαC-inType1 · XVI
Resolution
2.725 Å
R-value
0.216
Predicted activity confidence93.4%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAESQQDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCD
UniProt reference sequence
YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM
Aligned reference sequence
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------CHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTWCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------SHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHSR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Activation segment
DFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-WCGSPPYAAPE
Binding pocket
RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLSPHIIRLYQVYLVTEYASGGEIFDHLVAFCHSRNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
XVI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8R4O, Chain A