8QLS Chain A
Serine/threonine-protein kinase 24 (STK24)
Inactive — 0.0%DFG-inαC-inType1.5_Front · VYH
Resolution
1.61 Å
R-value
0.151
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVATPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDAHHHHH
UniProt reference sequence
FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------EKIGKGS----------------FGEVFKGID--NR------------------------------------TQKVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSPYVTKYYGSYLKDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLEP--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGEVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIKQ--------------------------------SAYD-SKADIWSLGITAIELARG-----------------EPPHSE--------------------------------------------------LHPMKVLFLIPKN--NPPTLEGNYS-----------------------------------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------EKIGKGS----------------FGEVFKGID--NR------------------------------------TQKVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSPYVTKYYGSYLKDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLEP--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGEVKLADFGVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPFWMAPEVIKQ--------------------------------SAYD-SKADIWSLGITAIELARG-----------------EPPHSE--------------------------------------------------LHPMKVLFLIPKN--NPPTLEGNYS-----------------------------------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT--------------AKELLKHKFI
Activation segment
DFGVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPFWMAPE
Binding pocket
EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA
Ligand info
Orthosteric ligand
VYH
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8QLS, Chain A