8QLQ Chain A
Serine/threonine-protein kinase 24 (STK24)
Inactive — 0.3%DFG-inαC-outType1 · VY0
Resolution
1.64 Å
R-value
0.181
Predicted activity confidence0.3%
Structure info
Alternate conformationA
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDAHHHHHH
UniProt reference sequence
FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------EKIGKGS----------------FGEVFKGID--NR------------------------------------TQKVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSPYVTKYYGSYLKDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLEP--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGEVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIKQ--------------------------------SAYD-SKADIWSLGITAIELARG-----------------EPPHSE--------------------------------------------------LHPMKVLFLIPKN--NPPTLEGNYS-----------------------------------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------EKIGKGS----------------FGEVFKGID--NR------------------------------------TQKVVAIKIID--LEEA--E---------------------------IEDIQQEITVLSQC--------------------------DSPYVTKYYGSYLKDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLEP--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGEVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIKQ--------------------------------SAYD-SKADIWSLGITAIELARG-----------------EPPHSE--------------------------------------------------LHPMKVLFLIPKN--NPPTLEGNYS-----------------------------------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT--------------AKELLKHKFI
Activation segment
DFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPE
Binding pocket
EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA
Ligand info
Orthosteric ligand
VY0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8QLQ, Chain A