8Q77 Chain A
Casein kinase II subunit alpha' (CSNK2A2)
Active — 99.9%DFG-inαC-inAllosteric,Type1 · LN3
Resolution
1.255 Å
R-value
0.12
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNERVVVKILK--PVK-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNERVVVKILK--PVK-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Activation segment
DWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRGKYSEVFEVVVKILKIKREVKILENLRTNIIKLIDTALVFEYIN_NTDFKQLYQYCHSKGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
LN3
Allosteric ligand
LN3
Ligand typeAllosteric,Type1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8Q77, Chain A