8Q61 Chain A
RAC-beta serine/threonine-protein kinase (AKT2)
Inactive — 0.3%DFG-outαC-outType3 · K06
Resolution
2.32 Å
R-value
0.212
Predicted activity confidence0.3%
Structure info
Alternate conformationB
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GAMDEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYRLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVD
UniProt reference sequence
FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
Aligned reference sequence
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQ----------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFY-------------------------------------------------------RLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Activation segment
DFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKILHTVTESRVLQ__RPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGLC
Ligand info
Orthosteric ligand
K06
Allosteric ligand
None
Ligand typeType3
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8Q61, Chain A