8Q1Z Chain A
Serine/threonine-protein kinase VRK2 (VRK2)
Active — 99.8%DFG-inαC-inType1 · IKD
Resolution
1.85 Å
R-value
0.203
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms18
Missing residues5
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FPEGKVLDDMEGNQWVLGKKIGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQ
UniProt reference sequence
WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNP
Aligned reference sequence
WVLG----------------KKIGSGG----------------FGLIYLAFP--TNKPE---------------------------------KDARHVVKVEY--QE--------------------------------NGPLFSELKFYQRV--AKKDCIKKWIERKQLDY---------LGIPLFYGSGLTEF--KGRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRFMVMERLG---------------IDLQKISGQ--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFKKSTVLQLGIRMLDVLEYIHEN---------------------------------------------EYVHGDI-----KAANLLLGY--KN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDQVYLADYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLDAHKG--------------------------------VALS-RRSDVEILGYCMLRWLCG-----------------KLPWEQ--NL----------------------------------------------KDPVAVQTAKTNL--LDELPQSVLKWAPSGSSC---------------------------------------------------------------------------------------------CEIAQFLVCAHSLAYDEKPN--------------YQALKKILNP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WVLG----------------KKI---------------------GLIYLAFP--TNKPE---------------------------------KDARHVVKVEY--QE--------------------------------NGPLFSELKFYQRV--AKKDCIKKWIERKQLDY---------LGIPLFYGSGLTEF--KGRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRFMVMERLG---------------IDLQKISGQ--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFKKSTVLQLGIRMLDVLEYIHEN---------------------------------------------EYVHGDI-----KAANLLLGY--KN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDQVYLADYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLDAHKG--------------------------------VALS-RRSDVEILGYCMLRWLCG-----------------KLPWEQ--NL----------------------------------------------KDPVAVQTAKTNL--LDELPQSVLKWAPSGSSC---------------------------------------------------------------------------------------------CEIAQFLVCAHSLAYDEKPN--------------YQALKKILNP
Activation segment
DYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLD
Binding pocket
KKI_____GLIYLHVVKVEPLFSELKFYQRVALGIPLFYGSFMVMERLG_IDLQKISGQYIHENEYVHGDIKAANLLLLADYGLS
Ligand info
Orthosteric ligand
IKD
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8Q1Z, Chain A