8PYR Chain A
Cyclin-dependent kinase 7 (CDK7)
Active — 99.9%DFG-inαC-in
Resolution
2.15 Å
R-value
0.223
Predicted activity confidence99.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues19
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGPNRAYHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN
UniProt reference sequence
YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
Aligned reference sequence
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
----------------------------------------------------------------------------------------------------------GHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFG-PNRA--Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Activation segment
DFGLAKSFG-PNRA--Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HQVVTRWYRAPE
Binding pocket
___________________TALREIKLLQELSPNIIGLLDASLVFDFME_TDLEVIIKDYLHQHWILHRDLKPNNLLLLADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8PYR, Chain A