8PYK Chain A
Insulin-like growth factor 1 receptor (IGF1R)
Inactive — 31.6%DFG-outαC-outType2 · IC2
Resolution
2.23 Å
R-value
0.201
Predicted activity confidence31.6%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)—
Sequence info
PDB sequence
—
UniProt reference sequence
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
Aligned reference sequence
ITMS----------------RELGQGS----------------FGMVYEGVA--KGVVKDE-------------------------------PETRVAIKTVN--EAASMRE---------------------------RIEFLNEASVMKEF--------------------------NCHHVVRLLGVVSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVIMELMTR--------------GDLKSYLRS--LRPEMENNPVLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLSKMIQMAGEIADGMAYLNAN---------------------------------------------KFVHRDL-----AARNCMVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMSPESLKD--------------------------------GVFT-TYSDVWSFGVVLWEIATL--A--------------EQPYQG--------------------------------------------------LSNEQVLRFVMEG--GLLDKPDNCP-----------------------------------------------------------------------------------------------------DMLFELMRMCWQYNPKMRPS--------------FLEIISSIKE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
—
Activation segment
—
Binding pocket
RELGQGSFGMVYEVAIKTVEFLNEASVMKEFN_HVVRLLGVLVIMELMTRGDLKSYLRSYLNANKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
IC2
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8PYK, Chain A