8PQH Chain A
Platelet-derived growth factor receptor alpha (PDGFRA)
Active — 88.3%DFG-inαC-inType1 · 9JI
Resolution
2.5 Å
R-value
0.22
Predicted activity confidence88.3%
Structure info
Alternate conformation—
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YEIRWRVIESIPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIIEYCFYGDLVNYLHKNRDSFLLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLK
UniProt reference sequence
LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN
Aligned reference sequence
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYCFY--------------GDLVNYLHK--NRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIIIEYCFY--------------GDLVNYLHK--NRDSFL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Activation segment
DFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPE
Binding pocket
RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIIIEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA
Ligand info
Orthosteric ligand
9JI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8PQH, Chain A