8PQF Chain A
Mast/stem cell growth factor receptor Kit (KIT)
Active — 88.5%DFG-inαC-inType1 · 9KI
Resolution
1.9 Å
R-value
0.197
Predicted activity confidence88.5%
Structure info
Alternate conformationB
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGPTLVITEYCCYGDLLNFLRRKRDEFVPYDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
UniProt reference sequence
LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
Aligned reference sequence
LSFG----------------KTLGAGA----------------FGKVVEATA--YGLIKSD-------------------------------AAMTVAVKMLK--PSAHLTE---------------------------REALMSELKVLSYL--G-----------------------NHMNIVNLLGACTIGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDLEDLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRITKICDFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------CVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMLSPEHAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT--------------FKQIVQLIEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSFG----------------KTLGAGA----------------FGKVVEATA--QGLIKSD-------------------------------AAMTVAVKMLK--PSAHSTE---------------------------REALMSELKVLSYL--G-----------------------NHENIVNLLGACT-HG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDEF------------------------------------------VP---------------------------YD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNITKICDFGLARDIKNDSNY--V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNARLPVKWMAPESIFN--------------------------------SVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMSSPEYAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPDKRPT--------------FKQIVQDIEK
Activation segment
DFGLARDIKNDSNY--V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNARLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
9KI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8PQF, Chain A