8PQB Chain A
Mast/stem cell growth factor receptor Kit (KIT)
Inactive — 19.3%DFG-inαC-inType1 · 9XO
Resolution
1.87 Å
R-value
0.2
Predicted activity confidence19.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKRLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
UniProt reference sequence
LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
Aligned reference sequence
LSFG----------------KTLGAGA----------------FGKVVEATA--YGLIKSD-------------------------------AAMTVAVKMLK--PSAHLTE---------------------------REALMSELKVLSYL--G-----------------------NHMNIVNLLGACTIGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDLEDLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRITKICDFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------CVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMLSPEHAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT--------------FKQIVQLIEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSFG----------------KTLGAGA----------------FGKVVEATA--QGL-------------------------------------MTVAVKMLK--PSAHSTE---------------------------REALMSELKVLSYL--G-----------------------NHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDEF------------------------------------------VPYK--------------------------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNITKICDFGLARDIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVKWMAPESIFN--------------------------------SVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMSSPEYAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPDKRPT--------------FKQIVQDIEK
Activation segment
DFGLARDIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
9XO
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8PQB, Chain A