8P4Z Chain A
Cyclin-dependent kinase 7 (CDK7)
Inactive — 0.0%DFG-inαC-outType1 · WZ8
Resolution
2.75 Å
R-value
0.226
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKINRTALREIKLLQELSHPNIIGLLDAFSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRP
UniProt reference sequence
YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
Aligned reference sequence
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKK--------------I-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAF---S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Activation segment
DFGLAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTRWYRAPE
Binding pocket
DFLGEGQFATVYKVAIKKITALREIKLLQELSPNIIGLLDASLVFDFME_TDLEVIIKDYLHQHWILHRDLKPNNLLLLADFGLA
Ligand info
Orthosteric ligand
WZ8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8P4Z, Chain A