8OMV Chain A
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Inactive — 0.0%DFG-outαC-out
Resolution
4.16 Å
R-value
0.259
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues11
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TTQTCGAWEMKERGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIYAKELGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVR
UniProt reference sequence
WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILN
Aligned reference sequence
WEMK----------------ERLGTGG----------------FGNVIRWHN--QE------------------------------------TGEQIAIKQCR--QELSPRN---------------------------RERWCLEIQIMRRL--------------------------THPNVVAARDVPEGMQ--NLAPND------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPLLAMEYCQG--------------GDLRKYLNQ--FENCC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLREGAILTLLSDIASALRYLHEN---------------------------------------------RIIHRDL-----KPENIVLQQ--GEQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLIHKIIDLGYAKELDQGSLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSFVGTLQYLAPELLEQ--------------------------------QKYT-VTVDYWSFGTLAFECITG-----------------FRPFLP--N-----------------------------------------------WQPVQWHSKVRQK--SEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLA-------------------------------------------------------------------------------ERLEKWLQLMLMWHPRQRGT--DPTYGPNG----CFKALDDILN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEMK----------------ER----------------------GNVIRWHN--QE------------------------------------TGEQIAIKQCR--QELSPRN---------------------------RERWCLEIQIMRRL--------------------------THPNVVAARDVPEGMQ--NLAPND------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPLLAMEYCQG--------------GDLRKYLNQ--FENCC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLREGAILTLLSDIASALRYLHEN---------------------------------------------RIIHRDL-----KPENIVLQQ--GEQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLIHKII---YAKEL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLQYLAPELLEQ--------------------------------QKYT-VTVDYWSFGTLAFECITG-----------------FRPFLP--N-----------------------------------------------WQPVQWHSKVRQK--SEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLA-------------------------------------------------------------------------------ERLEKWLQLMLMWHPRQRGT--DPTYGPNG----CFKALDDILN
Activation segment
---YAKEL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLQYLAPE
Binding pocket
IAIK_L___RERLIRRL_PVV_____PLLMYCQ_GDRKYLNQYLHENRIIHRDLKPENILIIPE
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8OMV, Chain A