8OKU Chain A
Serine/threonine-protein kinase SIK3 (SIK3)
Active — 98.1%DFG-inαC-inType1 · VRU
Resolution
3.1 Å
R-value
0.216
Predicted activity confidence98.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MHHHHHHLVPRGSPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKDWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL
UniProt reference sequence
YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM
Aligned reference sequence
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------CHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTWCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------RTIGKGN----------------FAVVKRATH--LV------------------------------------TKAKVAIKIID--KTQLDEEN--------------------------LKKIFREVQIMKML--------------------------CHPHIIRLYQVMETER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIYLVTEYASG--------------GEIFDHLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLNIKIADFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWCGSPPYAAPELFEG--------------------------------KEYDGPKVDIWSLGVVLYVLVCG-----------------ALPFDG--------------------------------------------------STLQNLRARVLSG--KFRIPFFMS------------------------------------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS--------------MEQICKHKWM
Activation segment
DFGFSNLFTPGQLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWCGSPPYAAPE
Binding pocket
RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLCPHIIRLYQVYLVTEYASGGEIFDHLVAFCHCRNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
VRU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8OKU, Chain A