8KFQ Chain A
Epidermal growth factor receptor (EGFR)
Active — 76.4%DFG-inαC-inType1 · VUZ
Resolution
3.22 Å
R-value
0.206
Predicted activity confidence76.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRAEDMDDVVDADEYLI
UniProt reference sequence
FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
Aligned reference sequence
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLITQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKEL-----TSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLIMQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGRAKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Activation segment
DFGRAKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGRA
Ligand info
Orthosteric ligand
VUZ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8KFQ, Chain A