8JF3 Chain A
Proto-oncogene tyrosine-protein kinase Src (SRC)
Inactive — 2.5%DFG-inαC-outType1 · C0N
Resolution
2.84648 Å
R-value
0.278
Predicted activity confidence2.5%
Structure info
Alternate conformation—
Missing atoms21
Missing residues11
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KDAWEIPRESLRVKLGEVWMGTWNGTTRVAIKTAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
UniProt reference sequence
LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED
Aligned reference sequence
LRLE----------------VKLGQGC----------------FGEVWMGTW--N-------------------------------------GTTRVAIKTLK--PGTMS-----------------------------PEAFLQEAQVMKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMSK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMAAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVADFGLARLIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ESLR----------------VKL---------------------GEVWMGTW--N-------------------------------------GTTRVAIKT---------------------------------------------AQVMKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMSK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMAAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVADFGLARL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Activation segment
DFGLARL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWTAPE
Binding pocket
VKLG_____EVWMVAIKT______AQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA
Ligand info
Orthosteric ligand
C0N
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8JF3, Chain A