8I2N Chain A
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Inactive — 13.2%DFG-outαC-outType1 · O4U
Resolution
2.29 Å
R-value
0.217
Predicted activity confidence13.2%
Structure info
Alternate conformation—
Missing atoms4
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LNVIKMKSSDFLESAELDSKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
UniProt reference sequence
FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRP
Aligned reference sequence
FLES----------------AELDSGG----------------FGKVSLCFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMCYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNELREVDGTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKNGGTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------ICEQQLIMCIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLES----------------AELDS--------------------KVSLAFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMAYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------IAEQQLIMAIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Activation segment
DLGLASFKMWSKLN--NEEHNEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLYYMAPE
Binding pocket
AELDS____KVSLMIMKTVALLEEAKMMNRLRSRVVKLLGVSLVMEYMEKGNLMHVLKAYLHGKGVIHKDLKPENILVIADLGLA
Ligand info
Orthosteric ligand
O4U
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8I2N, Chain A