8G66 Chain C
Casein kinase I isoform alpha (CSNK1A1)
Inactive — 33.7%DFG-inαC-in
Resolution
3.45 Å
R-value
0.215
Predicted activity confidence33.7%
Structure info
Alternate conformation—
Missing atoms9
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EFIVGGKYKLVRKIGSDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ
UniProt reference sequence
YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRI
Aligned reference sequence
YKLV----------------RKIGSGS----------------FGDIYLAIN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLLYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKLV----------------RKIGS--------------------DIYLAIN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLLYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNL-GTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Activation segment
DFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNL-GTARYASIN
Binding pocket
RKIGS____DIYLVAVKLEQLLYESKLYKILQVGIPHIRWYVLVMDLLG_PSLEDLFNFYVHTKNFIHRDIKPDNFLMLIDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8G66, Chain C