8FX4 Chain D
Guanylyl cyclase C (GUCY2C)
Inactive — 0.5%DFG-outαC-out
Resolution
3.9 Å
R-value
999.0
Predicted activity confidence0.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues41
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
TVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCLPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQ
UniProt reference sequence
LKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAK
Aligned reference sequence
LKID----------------DDKRRDT----------------IQRLRQCKY----------------------------------------DKKRVILKDLK--HNDGNF----------------------------TEKQKIELNKLLQI--------------------------DYYNLTKFYGTVKLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIFGVIEYCER--------------GSLREVLND--TISYPDGT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FMDWEFKISVLYDIAKGMSYLHSS--K------------------------------------------TEVHGRL-----KSTNCVVDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVVKITDFGCNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILPPKKDLWTAPEHLRQ--------------------------------ANIS-QKGDVYSYGIIAQEIILR-----------------KETFYT--LSC---------------------------------------------RDRNEKIFRVENS--NGMKPFRPDLFLETAEEKE--------------------------------------------------------------------------------------------LEVYLLVKNCWEEDPEKRPD--------------FKKIETTLAK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVKLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIFGVIEYCER--------------GSLREVLND--TISYPDGT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FMDWEFKISVLYDIAKGMSYLHSS--K------------------------------------------TEVHGRL-----KSTNCVVDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVVKITDFGC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPPKKDLWTAPEHLRQ--------------------------------ANIS-QKGDVYSYGIIAQEIILR-----------------KETFYT--LSC---------------------------------------------RDRNEKIFRVENS--NGMKPFRPDLFLETAEEKE--------------------------------------------------------------------------------------------LEVYLLVKNCWEEDPEKRPD--------------FKKIETTLAK
Activation segment
DFGC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPPKKDLWTAPE
Binding pocket
________________________________________TFGVIEYCERGSLREVLNDLHSSKTEVHGRLKSTNCVVITDFGC_
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8FX4, Chain D