8FAC Chain A
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
Inactive — 0.0%DFG-inαC-out
Resolution
3.92 Å
R-value
999.0
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LSHLPPGFLHLSKLQKLTASKNCLEKLFEGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAAMLSYLRAQKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSESAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENASFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQVYDEKVDMFSYGMVLYELLSQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRQHLQAVKILAVRDLIWVPRRGGDVIVIGLQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRK
UniProt reference sequence
LEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKD
Aligned reference sequence
LEHS--EDEG----------SVLGQGG----------------SGTVIYRAR--Y-------------------------------------QGQPVAVKRFH--IKKFKNFANVPADTMLRHLRATDAMKN-------FSEFRQEASMLHAL--------------------------QHPCIVALIGISIH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCFALELAPL--------------SSLNTVLSE--NARDSSFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGHMLTQKIAYQIASGLAYLHKK---------------------------------------------NIIFCDL-----KSDNILVWS--LDVKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HINIKLSDYGISRQSFHEGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGVEGTPGYQAPEIRPR--------------------------------IVYD-EKVDMFSYGMVLYELLSG-----------------QRPALG--HHQL--------------------------------------------QIAKKLSKGIRPV--LGQPEEVQF------------------------------------------------------------------------------------------------------RRLQALMMECWDTKPEKRPL--------------ALSVVSQMKD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEHS--EDEG----------SVLGQGG----------------SGTVIYRAR--Y-------------------------------------QGQPVAVKRFH--IKK-----------MLRHLRATDAMKN-------FSEFRQEASMLHAL--------------------------QHPCIVALIGISIH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCFALELAPL--------------SSLNTVLSE--NA---SFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGHMLTQKIAYQIASGLAYLHKK---------------------------------------------NIIFCDL-----KSDNILVWS--LDVKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HINIKLSDYGISRQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYD-EKVDMFSYGMVLYELLS----------------------------QL--------------------------------------------QIAKKLSKGIRPV--LGQPEEVQF------------------------------------------------------------------------------------------------------RRLQALMMECWDTKPEKRPL--------------ALSVVSQMKD
Activation segment
DYGISRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
P_LGQGNGTVYLIIVKSLALQREFNVMKNLQPNVVRILALQLITSMIPRSSLRDYLQTYFQEANYLHRITDFGL
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8FAC, Chain A