8EME Chain A
Epidermal growth factor receptor (EGFR)
Inactive — 0.2%DFG-inαC-out
Resolution
3.32 Å
R-value
0.285
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRRDLAARNVLVKTPQHVKITDFIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLPSPTDSNFYRALMDEEDM
UniProt reference sequence
FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
Aligned reference sequence
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLITQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKEL---------A---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLIMQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------R---RDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMRKCWMIDADSRPK--------------FRELIIEFSK
Activation segment
DF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGCLLDYVREYLEDRR___RDLAARNVLVITDF___
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8EME, Chain A