8EDH Chain A
Serine/threonine-protein kinase WNK3 (WNK3)
Inactive — 0.0%DFG-inαC-outType1 · WGK
Resolution
3.111 Å
R-value
0.196
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
AVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMEFMAPEMYYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFA
UniProt reference sequence
FLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
Aligned reference sequence
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--DRKLTKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLMRTSFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPEMYE---------------------------------EHYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTSG--IKPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--DRKLTKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFMAPEMY------------------------------------YD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTSG--IKPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Activation segment
DLGLATLM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFMAPE
Binding pocket
IELGRGAFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA
Ligand info
Orthosteric ligand
WGK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8EDH, Chain A