8CHF Chain A
RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Active — 93.4%DFG-inαC-inType1 · 29L
Resolution
4.25 Å
R-value
0.445
Predicted activity confidence93.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSAEPSLH
UniProt reference sequence
VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIEL
Aligned reference sequence
VMLS----------------TRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKILK--VVDPTPEQ--------------------------FQAFRNEVAVLRKT--------------------------RHVNILLFMGYMTKD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLAIVTQWCEG--------------SSLYKHLHV--QET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFQMFQLIDIARQTAQGMDYLHAK---------------------------------------------NIIHRDM-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTVKIGDFGLATVKSRWSGS--QQV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPTGSVLWMAPEVIRM--QDN---------------------------NPFS-FQSDVYSYGIVLYELMTG-----------------ELPYSH--I-----------------------------------------------NNRDQIIFMVGRG--YASPDLSKLYKNCP-------------------------------------------------------------------------------------------------KAMKRLVADCVKKVKEERPL--------------FPQILSSIEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VMLS----------------TRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKILK--VVDPTPEQ--------------------------FQAFRNEVAVLRKT--------------------------RHVNILLFMGYMTKD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLAIVTQWCEG--------------SSLYKHLHV--QET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFQMFQLIDIARQTAQGMDYLHAK---------------------------------------------NIIHRDM-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTVKIGDFGLATVKSR--------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPTGSVLWMAPEVIRM--QDN---------------------------NPFS-FQSDVYSYGIVLYELMTG-----------------ELPYSH--I-----------------------------------------------NNRDQIIFMVGRG--YASPDLSKLYKNCP-------------------------------------------------------------------------------------------------KAMKRLVADCVKKVKEERPL--------------FPQILSSIEL
Activation segment
DFGLATVKSR--------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPTGSVLWMAPE
Binding pocket
TRIGSGSFGTVYKVAVKILAFRNEVAVLRKTRVNILLFMGYAIVTQWCEGSSLYKHLHVYLHAKNIIHRDMKSNNIFLIGDFGLA
Ligand info
Orthosteric ligand
29L
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8CHF, Chain A