8C2Z Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B)
Active — 75.5%DFG-inαC-inType1 · QS0
Resolution
1.91 Å
R-value
0.179
Predicted activity confidence75.5%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT
UniProt reference sequence
YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
Aligned reference sequence
YEID----------------SLIGKGS----------------FGQVVKAYD--HQ------------------------------------TQELVAIKIIK--NKKAF-----------------------------LNQAQIELRLLELM--NQHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFELLS---------------YNLYDLLRN--THFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKLAQQLCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQYIQSRFYRSPEVLLG--------------------------------TPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------SNEVDQMNRIVEV--LGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADY--------------------------------------LRFQDLVLRMLEYEPAARIS--------------PLGALQHGFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------SLIGKGS----------------FGQVVKAYD--HQ------------------------------------TQELVAIKIIK--NKKAF-----------------------------LNQAQIELRLLELM--NQHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFELLS---------------YNLYDLLRN--THFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKLAQQLCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPEVLLG--------------------------------TPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------SNEVDQMNRIVEV--LGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGV-------------GHSPADY--------------------------------------LRFQDLVLRMLEYEPAARIS--------------PLGALQHGFF
Activation segment
DFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPE
Binding pocket
SLIGKGSFGQVVKVAIKIIQAQIELRLLELMNYYIVHLKRHCLVFELLS_YNLYDLLRNATPELSIIHCDLKPENILLIVDFGSS
Ligand info
Orthosteric ligand
QS0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8C2Z, Chain A