8C12 Chain A
Serine/threonine-protein kinase PAK 5 (PAK5)
Inactive — 31.6%DFG-inαC-in
Resolution
1.549 Å
R-value
0.199
Predicted activity confidence31.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)—
Sequence info
PDB sequence
—
UniProt reference sequence
LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
Aligned reference sequence
LANF----------------IKIGEGS----------------TGIVCIATE--KH------------------------------------TGKQVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------HHDNVVDMYSSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIATVCLSVLRALSYLHNQ---------------------------------------------GVIHRDI-----KSDSILLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRIKLSDFGFCAQVSKEVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPEVISR--------------------------------LPYG-TEVDIWSLGIMVIEMIDG-----------------EPPYFN--------------------------------------------------EPPLQAMRRIRDS--LPPRVKDLHKVS---------------------------------------------------------------------------------------------------SVLRGFLDLMLVREPSQRAT--------------AQELLGHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
—
Activation segment
—
Binding pocket
IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYHDNVVDMYSSWVVMEFLEGGALTDIVTHYLHNQGVIHRDIKSDSILLLSDFGFC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8C12, Chain A