8BFS Chain A
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
Inactive — 0.0%DFG-inαC-outType1 · QNR
Resolution
1.95 Å
R-value
0.168
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms4
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFA
UniProt reference sequence
FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI
Aligned reference sequence
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFGLSKMEGKGDVM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Activation segment
DFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPE
Binding pocket
ETLGTGAFSEVVLFAVKCISIENEIAVLRKIKENIVALEDIYLVMQLVSGGELFDRIVEYLHRMGIVHRDLKPENLLYISDFG__
Ligand info
Orthosteric ligand
QNR
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8BFS, Chain A