8BFM Chain A
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
Inactive — 0.1%DFG-inαC-outType1,Type3 · QI6
Resolution
1.7 Å
R-value
0.201
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms24
Missing residues2
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGGYVAPEVLYSKAVDCWSIGVIAYILLCGYPPFYDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF
UniProt reference sequence
FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI
Aligned reference sequence
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFGLSKMEGKGDVM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYVAPEVL------------------------------------YS-KAVDCWSIGVIAYILLCG-----------------YPPFY-----------------------------------------------------DSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Activation segment
DFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYVAPE
Binding pocket
ETLGTGAFSEVVLFAVKCISIENEIAVLRKIKENIVALEDIYLVMQLVSGGELFDRIVEYLHRMGIVHRDLKPENLLYISDFG__
Ligand info
Orthosteric ligand
QI6
Allosteric ligand
None
Ligand typeType1,Type3
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8BFM, Chain A