8A8M Chain B
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Inactive — 42.6%DFG-inαC-inType1 · AP2
Resolution
4.0 Å
R-value
999.0
Predicted activity confidence42.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
LLERRGVSELPPLYCISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
UniProt reference sequence
LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
Aligned reference sequence
LEPI----------------MELGRGA----------------YGVVEKMRH--VP------------------------------------SGQIMAVKRIR--ATVNSQE---------------------------QKRLLMDLDISMRT--V-----------------------DCPFTVTFYGALFREG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVWICMELMD---------------TSLDKFYKQ--VIDKGQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPEDILGKIAVSIVKALEHLHSK--L------------------------------------------SVIHRDV-----KPSNVLINA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGQVKMCDFGISGYLVDSVAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIDAGCKPYMAPERINP--ELNQ--------------------------KGYS-VKSDIWSLGITMIELAIL-----------------RFPYDS--W-----------------------------------------------GTPFQQLKQVVEE--PSPQLPADKFS----------------------------------------------------------------------------------------------------AEFVDFTSQCLKKNSKERPT--------------YPELMQHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEPI----------------MELGRGA----------------YGVVEKMRH--VP------------------------------------SGQIMAVKRIR--ATVNSQE---------------------------QKRLLMDLDISMRT--V-----------------------DCPFTVTFYGALFREG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVWICMELMD---------------TSLDKFYKQ--VIDKGQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPEDILGKIAVSIVKALEHLHSK--L------------------------------------------SVIHRDV-----KPSNVLINA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGQVKMCDFGISGYL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYMAPERINP--ELNQ--------------------------KGYS-VKSDIWSLGITMIELAIL-----------------RFPYDS--W-----------------------------------------------GTPFQQLKQVVEE--PSPQLPADKFS----------------------------------------------------------------------------------------------------AEFVDFTSQCLKKNSKERPT--------------YPELMQHPFF
Activation segment
DFGISGYL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYMAPE
Binding pocket
MELGRGAYGVVEKMAVKRIRLLMDLDISMRTVPFTVTFYGAWICMELMD_TSLDKFYKQLHSKLSVIHRDVKPSNVLIMCDFGIS
Ligand info
Orthosteric ligand
AP2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8A8M, Chain B